SiteHound-web identifies ligand binding sites by computing interactions between a chemical probe and a protein structure.

The input is a PDB file of a protein structure, the output is a list of “interaction energy clusters” corresponding to putative binding sites.

Selecting a different chemical probe may result in the identification of a different type of binding site.

· Authorship, Publications, and Disclaimers

· Changes and Technical information

· Standalone SiteHound and manual

Please specify a PDB file or a PDB ID:


Clustering Algorithm 

 Single    Average

Sample Input: [1kna]  
Sample Output: [1kna with CMET probe]  

Users of SiteHound-web are requested to cite this article in their publications:
SITEHOUND-web: a server for ligand binding site identification in protein structures.
M. Hernandez, et al., 2009.

Please address all inquiries to